Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of Zhen-wu decoction on chronic heart failure in rats

Zhongyong Liu, Lin Li , Shihua Luo, Jia Fang

Department of Cardiovascular, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Jiangxi Province, Nanchang, China;

For correspondence:- Lin Li Email: lilin494133@sina.com Tel:+8679186362753

Accepted: 21 September 2017 Published: 31 October 2017

Citation: Liu Z, Li L, Luo S, Fang J. Effect of Zhen-wu decoction on chronic heart failure in rats. Trop J Pharm Res 2017; 16(10):2439-2443 doi: 10.4314/tjpr.v16i10.18

© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the effect of Zhen-wu decoction (ZWD) on oxidative stress and hemodynamics in chronic congestive heart failure (CHF) rats.

Methods: After Sprague Dawley (SD) rats were successfully prepared into CHF, they were randomly divided into normal control group, model (untreated CHF) group, captopril group, high-dose, middle-dose and low-dose of ZWD groups, and were treated with drugs for 4 weeks respectively. At the end of the experiment, hemodynamic function, whole heart weight index, blood creatinine kinase (CK), superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO) and nitric oxide synthase (NOS) were determined.

Results: Compared with normal control group, ZWD group showed decreased arterial systolic pressure (SBP, 89.16 ± 17.27 mmHg), diastolic pressure (DBP, 72.54 ± 22.36 mmHg), mean arterial pressure (MAP, 72.64 ± 11.87 mmHg), heart rate (HR, 368.25 ± 39.12 beats/min), left ventricular systolic peak (LVSP, 105.27 ± 15.23 mmHg), and left ventricular pressure change rate (dp/dt max) (p < 0.05), while left ventricular end diastolic pressure (LVEDP) (19.52 ± 1.89 mmHg), whole heart weight index (2.74 ± 0.16 mg/g), blood CK (0.98 ± 0.16 U/mL), MDA (17.28 ± 2.94 nmol/mL), NO (36.35 ± 3.27 umol/L), NOS (39.89 ± 3.56 U/mL) significantly increased (p < 0.05). High dose of ZWD significantly improved hemodynamic function, lowered MDA (8.85 ± 2.14 nmol/mL) and NO (24.25 ± 3.21 umol/L) levels (p < 0.05), and also decreased CK (0.58 ± 0.37 U/mL) and NOS (26.12 ± 3.87 U/mL) in CHF rats (p < 0.05).

Conclusion: ZWD improves adriamycin-induced chronic congestive heart failure in rats significantly, and therefore has potential to be developed for the management of chronic congestive heart failure.

Keywords: Zhen-wu decoction, Chronic heart failure, Hemodynamic function, Oxidative stress